A native of Seville, Sergio learnt his trade at his local club. From 2006 to 2011 as a junior, then as a pro from 2014 to 2020, the Andalusian goalkeeper was between the posts of FC Sevilla, winning the UEFA Europa League twice (2015 and 2016).
After a season in the Premier League with Fulham, Sergio signed a one-year loan contract with Paris Saint-Germain. A much liked and respected member of the squad and after some outstanding performances, the Spaniard signed a four-year contract. Following half a season on loan at Mallorca, he returned to Paris in summer 2022.